Electrode placement accuracy was determined by analyzing postoperative CT scans laid over preoperative virtual electrode trajectory paths. Gadolinium deposition has raised safety concerns, but it is unknown whether ferumoxytol administration also deposits in the brain. RSNA, 2018 Online supplemental material is available for this article. Readers correctly and concordantly triaged 70 of 73 patients (96%) to ET (=0.938; P=0.855) and correctly excluded 143 of 146 patients (98%; P=0.942). Michael L Stanford, Willis, TX . Intra-observer variation for the calculated EF with CT were 13.6% and 15.6% for Readers 1 and 2, respectively. To optimize outcomes reporting, prospective trials in brain metastases should incorporate central imaging review and investigator training. We observed in our practice at an academic center that the times to perform functional MR imaging examinations were excessively lengthy, making scheduling of the examination difficult. Intermodality agreement was excellent between Fe-SPGR and DSA ( = 1.00) but poor between ASL and DSA ( = 0.53; 95% CI 0.18-0.89). Leptomeningeal carcinomatosis (LM) is a severe complication of non-small-cell lung cancer (NSCLC) historically associated with poor prognosis. View details for DOI 10.1371/journal.pone.0129325, View details for Web of Science ID 000356327000065. Consensus agreement among physician raters reporting hypothetic changes in treatment-related decisions based on fractional tumor burden was compared with actual real-time treatment decisions.Mean low fractional tumor burden, high fractional tumor burden, and relative CBV of the contrast-enhancing volume were significantly different between treatment effect and tumor (P=.002, P View details for DOI 10.3174/ajnr.A6211 View details for PubMedID 31515215. Diagnostic functional MR imaging requires extensive patient interaction as well as the coordinated efforts of the entire health care team. Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more. In addition, we aimed to analyze CSF biomarkers for dementia and associations with CSF metal levels.This is a cross-sectional study of 196 patients who underwent memory clinic investigation, including brain MRI. AUC for using normalized TBF to identify tumor vascularity on DSA was 0.82 (95% CI, 0.72-0.91), and a normalized TBF cut point of 2.7 yielded 88% sensitivity and 67% specificity. Advanced Imaging of Brain Metastases: From Augmenting Visualization and Improving Diagnosis to Evaluating Treatment Response. As such, it may further delineate functional and dysfunctional neuronal networks, guide stroke interventions, and improve prognosis and monitoring of patient outcomes. Jump to: Criminal Records, Social Media. 1701 Page Mill Road. MRI and histopathology support the mechanism of action to inhibit post-irradiation tumor revascularization.Infusion of the CXCR4 inhibitor plerixafor was well tolerated as an adjunct to standard chemo-irradiation in newly diagnosed GBM patients and improves local control of tumor recurrences. CORRELATION OF VASARI-BASED MRI PHENOTYPES WITH MGMT AND IDH STATUS ACROSS GLIOMA GRADES: A STATISTICAL ANALYSIS IN 372 PATIENTS. Lamsam, L., Quon, J., Fischbein, N., Iv, M., Dodd, R., Ratliff, J. Avoidance of radiation-induced optic neuropathy (RION) from stereotactic radiosurgery (SRS) requires precise anatomical localization; however, no prior studies have characterized the physiologic motion of the optic chiasm. Radiomics describes a broad set of computational methods that extract quantitative features from radiographic images. This work shows picomolar doses of pyridines with single methyl or ethyl substitutions significantly inhibit oviductal functioning raising questions regarding the safety of these compounds. There were 199 controls. Angiogenesis and hypoxia pathways were enriched in this subgroup of patients, suggesting the potential efficacy of antiangiogenic therapy. Functional magnetic resonance (MR) imaging is a complex, specialized examination that is able to noninvasively measure information critical to patient care such as hemispheric language lateralization ( 1 ). You can message your clinic, view lab results, schedule an appointment, and pay your bill. Histopathologic examination defined treatment effect versus tumor. Grovik, E., Yi, D., Iv, M., Tong, E., Rubin, D., Zaharchuk, G. Advanced Imaging of Brain Metastases: From Augmenting Visualization and Improving Diagnosis to Evaluating Treatment Response. View details for PubMedCentralID PMC7332795. Our purpose is to describe the association between demyelinating lesions and venous anomalies, as only one case of TD associated with a DVA has been published in the literature. The sensitivity and specificity for detecting residual AVMs using Fe-SPGR were 100% and 100%, and using ASL they were 72% and 100%, respectively. We review brain tumor radiologic studies (eg, imaging interpretation) through computational models (eg, computer vision and machine learning) that provide novel clinical insights. Page 1 of 7 Michael Iv Clinical Associate Professor, Radiology CLINICAL OFFICES • Stanford Neuroimaging and Neurointervention 300 Pasteur Dr Rm S031E MC 5105 Stanford, CA 94305 Bio Tel (650) 725-5384 Fax (650) 723-1909 BIO Dr. Michael Iv received his medical degree from the David Geffen School of Medicine at UCLA. LM was defined by cerebrospinal fluid (CSF) that was positive for malignant cells or by LM enhancement on magnetic resonance imaging with gadolinium contrast. One potential application is to create models depicting neurosurgical pathology. Yoon, B. C., Saad, A. F., Rezaii, P., Wintermark, M., Zaharchuk, G., Iv, M. Radiomics in Brain Tumor: Image Assessment, Quantitative Feature Descriptors, and Machine-Learning Approaches. Contrast-enhanced magnetic resonance imaging (MRI) is the traditional imaging method for the evaluation of brain metastases, as it provides information about lesion size, morphology, and macroscopic properties. Jabarkheel, R., Tong, E., Lee, E. H., Cullen, T. M., Yousaf, U., Loening, A. M., Taviani, V., Iv, M., Grant, G. A., Holdsworth, S. J., Vasanawala, S. S., Yeom, K. W. A PHASE 1 STUDY OF BPM31510 PLUS VITAMIN K IN SUBJECTS WITH HIGH-GRADE GLIOMA THAT HAS RECURRED ON A BEVACIZUMAB-CONTAINING REGIMEN. Future multicenter studies could further investigate the efficacy of Fe-MRI as a noninvasive alternative to DSA for monitoring AVMs in children. However, major challenges remain for methodologic developments to optimize feature extraction and provide rapid information flow in clinical settings. Huang, Y., Singer, T. G., Iv, M., Lanzman, B., Nair, S., Stadler, J. He, J. Q., Iv, M., Li, G., Zhang, M., Hayden-Gephart, M. Nodular Leptomeningeal Disease - A Distinct Pattern of Recurrence After Post-Resection Stereotactic Radiosurgery for Brain Metastases: A Multi-Institutional Study of Inter-Observer Reliability. Krishnam, M. S., Tomasian, A., Iv, M., Ruehm, S. G., Salieh, R., Panknin, C., Goldin, J. G. Cardiac hemangioma: Features on cardiovascular magnetic resonance. View details for DOI 10.1080/10976640701693642, View details for Web of Science ID 000251394000007. Age 71. View details for DOI 10.1158/1078-0432.CCR-19-1421, Resection of deep intracranial cavernous malformations (CMs) is associated with a higher risk of neurological deterioration and uncertainty regarding clinical outcomes.To examine diffusion tractography imaging (DTI) data evaluating the corticospinal tract (CST) in relation to motor and functional outcomes in patients with surgically resected deep CMs.Perilesional CST was characterized as disrupted, displaced, or normal. Dr. Michael Iv received his medical degree from the David Geffen School of Medicine at UCLA. Multivariable regression analysis was used for statistical analysis.A total of 18 patients [brainstem (15) and thalamus/basal ganglia (3); median follow-up: 270 d] were identified over 2 yr. Five of 6 patients with disruption had weakness. Elizabeth Tong MD. Narrow Your Results . Two experienced raters graded AVMs using Spetzler-Martin criteria on all imaging studies. For ASL, signal in the DVA, surrounding parenchyma, or associated draining vein was recorded. OF STANFORD UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE: OF DOCTOR OF PHILOSOPHY JUNE 1979 . Zhang, M., Telischak, N. A., Fischbein, N. J., Steinberg, G. K., Marks, M., Zaharchuk, G., Heit, J. J., Iv, M. Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic treatment. The primary efficacy measure is the California Verbal Learning Test-II (CVLT-II), assessed 1week after intervention. Get the Android MyHealth app ». We examined cerebral hemodynamic properties of pediatric LCH using arterial spin-labeling (ASL) perfusion magnetic resonance imaging (MRI).A retrospective study was performed in 23 children with biopsy-proven LCH. Select any poster below to play the movie, totally free! ASL abnormalities were seen in 21/248 (8%), including signal in a draining vein (2/21, 10%), in the DVA (11/21, 52%), and in the parenchyma (8/21, 38%). Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. An increase in CSF iron with the number of CMBs was seen in APOE4 carriers.CSF iron levels are elevated with cerebral microbleeds in APOE4 carriers, with no other association seen with hemorrhagic markers of small vessel disease. ASL signal in relation to the venous anomaly was identified in: 50% in the adjacent parenchyma, 33% in the lesion, 7% in a distal draining vein/sinus, and 10% in at least two of these sites. In this article, we report a case of critical illness-associated cerebral microbleeds identified on MRI in a patient with severe COVID-19 infection and discuss the potential etiologies of these neuroimaging findings. Therefore, two cortical sites will be investigated in this trial: (1) the dorsolateral prefrontal cortex (DLPFC), which has been well studied for treatment of major depressive disorder; and (2) the lateral parietal cortex (LPC), a novel site with connectivity to AD-relevant limbic regions.In this single-site trial, we plan to enroll 99 participants with single or multi-domain amnestic MCI. Turner, B. E., Prabhu, R. S., Burri, S. H., Brown, P. D., Pollom, E. L., Milano, M. T., Weiss, S. E., Iv, M., Fischbein, N., Soliman, H., Lo, S. S., Chao, S. T., Cox, B. W., Murphy, J. D., Li, G., Gephart, M. H., Nagpal, S., Atalar, B., Azoulay, M., Thomas, R., Tillman, G., Durkee, B. Y., Shah, J. L., Soltys, S. G. Ferumoxytol-enhanced MRI for surveillance of pediatric cerebral arteriovenous malformations. The purpose of this study was to evaluate the prevalence and significance of concurrent coccidioidal brain and intraspinal disease.We conducted a retrospective imaging review of 23 patients with proven coccidioidal CNS meningitis.All patients had intracranial abnormalities, and 86% (19/22) who underwent spinal imaging had signs of intraspinal disease, including leptomeningeal enhancement (84%), arachnoiditis (63%), and cord signal abnormalities (37%); seven of 15 patients (47%) who underwent myelography had complete spinal blocks.The high prevalence of concurrent brain and intraspinal coccidioidomycosis supports a low threshold for spinal imaging. Michael Keller Vice Provost, Academic Council, Stanford University Libraries Curriculum Vitae available Online CONTACT INFORMATION • Alternate Contact Mariellen F. Calter - Deputy University Librarian Email mcalter@stanford.edu Tel 650-723-5553 Bio ACADEMIC APPOINTMENTS • Vice Provost, Academic Council, Stanford University Libraries The purpose of this study was to evaluate the feasibility and reliability of software-based quantification of left ventricular function using 64-slice CT coronary angiography. Read the latest > Información sobre el coronavirus 2019 (COVID-19). 1701 Page Mill Road. DE-EPI DWI data were acquired in 18 pediatric patients with abnormal diffusion lesions, and 46 pediatric patient controls at 3T. Surprising Things You Didn't Know About Dogs and Cats Institutions. Deep Learning Enables Automatic Detection and Segmentation of Brain Metastases on Multisequence MRI. Send Cancel Tod und Auferstehung Jesu Christi bei Iuvencus IV 570-812 : Untersuchungen zu Dichtkunst, Theologie und … Nine to twelve months later, pigs were sacrificed and the brains of all pigs underwent ex vivo MRI at 7T with T2 and T2*-weighted sequences. Because few rTMS trials have been conducted in MCI, we designed a trial to test the short-term efficacy of rTMS in MCI. Brain iron deposition after Ferumoxytol-enhanced MRI: A study of Porcine Brains. Law. Ten percent presented with acute symptoms, only one of whom presented with hemorrhage. Information about the 2019 Novel Coronavirus. Imaging Manifestations of Primary and Disseminated Coccidioidomycosis. Prolonged survival of patients with non-small-cell lung cancer with leptomeningeal carcinomatosis in the modern treatment era. Pig brains were sectioned and stained with Prussian blue and evaluated for iron deposition using a semiquantitative scoring system. View insurance information for Michael Iv, doctor in Stanford, CA. A., Huang, Y., Lee, E. H., Iv, M., Moseley, M. E., Holdsworth, S. J., Yeom, K. W. Variable Refocusing Flip Angle Single-Shot Imaging for Sedation-Free Fast Brain MRI. The apparent diffusion coefficient (ADC) map from Echo1 was used to validate presence of true pathology. View details for DOI 10.1016/j.clinimag.2020.08.029. Sensitivity, specificity, and intermodality reliability were determined using DSA studies as the gold standard. Two blinded readers independently assessed pTOF derived from 3D ME-GRE and compared them with cTOF. Information for Dr. Michael Iv at Stanford Children's Health. View details for DOI 10.1007/s00234-020-02499-5, Conventional single-shot FSE commonly used for fast MRI may be suboptimal for brain evaluation due to poor image contrast, SNR, or image blurring. Deep learning model performance was compared against that of 4 radiologists.Model tumor detection accuracy exceeded an AUROC of 0.99 and was similar to that of 4 radiologists. Symptoms did not localize to the venous anomaly in 90%. High-resolution 3D volumetric contrast-enhanced MR angiography with a blood pool agent (ferumoxytol) for diagnostic evaluation of pediatric brain arteriovenous malformations. Cox survival and gene set enrichment analyses were conducted to characterize the clinical significance and molecular pathway activities of the clusters. Mean susceptibility and R2* values of the dentate (first MRI: 0.06 ppm 0.05 and 25.78 sec-1 5.9; last MRI: 0.06 ppm 0.02 and 25.55 sec-1 4.71), substantia nigrae (first MRI: 0.06 ppm 0.06 and 28.26 sec-1 9.56; last MRI: 0.07 ppm 0.06 and 25.65 sec-1 6.37), globus pallidi (first MRI: 0.13 ppm 0.07 and 27.53 sec-1 8.88; last MRI: 0.14 ppm 0.06 and 29.78 sec-1 6.54), putamina (first MRI: 0.03 ppm 0.03 and 19.78 sec-1 3.51; last MRI: 0.03 ppm 0.02 and 19.73 sec-1 3.01), caudate (first MRI: -0.09 ppm 0.05 and 21.38 sec-1 4.72; last MRI: -0.1 ppm 0.05 and 18.75 sec-1 2.68), and thalami (first MRI: 0.01 ppm 0.02 and 17.65 sec-1 5.16; last MRI: 0 ppm 0.02 and 15.32 sec-1 2.49) did not differ between the first and last MRI examinations (susceptibility, P = .95; R2*, P = .54). MATERIALS AND METHODS. Be sure to call ahead with Dr. Iv to book an appointment. Iv, M., Choudhri, O., Dodd, R. L., Vasanawala, S. S., Alley, M. T., Moseley, M., Holdsworth, S. J., Grant, G., Cheshier, S., Yeom, K. W. Can diffusion- and perfusion-weighted imaging alone accurately triage anterior circulation acute ischemic stroke patients to endovascular therapy? Age 71. We conclude by discussing future directions in DTI research in TBI including the role of machine learning in the pattern classification of TBI. Distinct molecular subgroups of pediatric medulloblastoma confer important differences in prognosis and therapy. Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion. To investigate the frequency and characteristics of developmental venous anomaly (DVA)-associated perfusion abnormalities on arterial spin labeling (ASL) and bolus perfusion-weighted imaging (PWI) and discuss their potential causes.We reviewed brain MR reports to identify all DVAs reported on studies performed between 2009 and 2012. We conducted a phase I/II study to determine the safety and efficacy of Macrophage Exclusion after Radiation Therapy (MERT) using the reversible CXCR4 inhibitor plerixafor in newly diagnosed glioblastoma patients.We enrolled 9 patients to the phase I study and an additional 20 patients to phase II using a modified toxicity probability interval (mTPI) design. (Stanford users can avoid this Captcha by logging in.) Currently, tissue sampling is the only method to obtain information for classification. This work concludes that DE-EPI DWI is a useful alternative to conventional single-echo EPI DWI, whereby Echo2 and cEcho2 allows for improved lesion detection and overall higher diagnostic confidence. The Cohen was used to determine interrater agreement. He is board certified in Diagnostic Radiology and also holds a Certificate of Added Qualification in Neuroradiology. Performance was assessed with an area under the receiver operating characteristic curve. Similarly, previously reported chiasm dose constraints may underestimate the true dose received during radiosurgery.To limit the risk of RION, clinicians may consider adding a 0.50 - 0.75mm expansion to the chiasm avoidance structure. This study aimed to evaluate the benefits of thick-slab overlapping MIPs constructed from contrast-enhanced T1-weighted CUBE (overlapping CUBE MIP) for the detection of brain metastases in comparison with traditional CUBE and inversion-recovery prepared fast-spoiled gradient recalled brain volume (IR-FSPGR-BRAVO) and nonoverlapping CUBE MIP.A retrospective review of 48 patients with cerebral metastases was performed at our institution from June 2016 to October 2017. Practical Pearl: Use of MRI to Differentiate Pseudo-subarachnoid Hemorrhage from True Subarachnoid Hemorrhage. We assembled a multidisciplinary team and retrospectively reviewed all functional MR imaging examinations performed at our institution from January 2013 to August 2015. Entry point, target point, and closest vessel intersection were measured.For any intersection along the trajectory path, 57 intersected vessels were measured. The diagnosis of such a rare entity can therefore be challenging, especially as it may mimic more aggressive lesions, including malignancy. Panesar, S. S., Magnetta, M., Mukherjee, D., Abhinav, K., Branstetter, B. F., Gardner, P. A., Iv, M., Fernandez-Miranda, J. C. Khalaf, A., Iv, M., Fullerton, H., Wintermark, M. Conus Medullaris Dural Arteriovenous Fistula Arising From the Artery of the Filum Terminale: 2-Dimensional Operative Video. They may be used as a visualization aid for surgeons and patients, or for education of trainees. This review discusses the imaging of congenital brain malformations encountered in patients who are younger than 2 years in the context of brain development. Economic History. The differential treatment efficacy of antiangiogenic therapy between the clusters was evaluated.A subgroup of patients with elevated perfusion features was identified and was significantly associated with poor patient survival after accounting for other clinical covariates (P values 3) consistently found in both cohorts. On coronal images, the average superior-inferior displacement was 0.42mm (95%CI 0.13 - 0.71mm), and the average lateral displacement was 0.75mm (95%CI 0.42 - 1.08mm). Non-Contrast T2-Weighted MR Sequences for Long Term Monitoring of Asymptomatic Convexity Meningiomas. Ho, A. L., Sussman, E. S., Pendharkar, A. V., Iv, M., Hirsch, K. G., Fischbein, N. J., Dodd, R. L. Lobular capillary hemangioma of the mandible: A case report. Phase I study of BPM31510 and vitamin K in patients with high grade glioma recurrent after a bevacizumab-containing regimen. Diffusion Tensor Imaging of TBI: Potentials and Challenges. Association of developmental venous anomalies with perfusion abnormalities on arterial spin labeling and bolus perfusion-weighted imaging. Each participant was administered intravenous ferumoxytol (5 mg/kg) and underwent 3.0-T MRI 24 hours later. Additional studies included relative cerebral blood volume (rCBV) analysis using MRI and histopathology analysis of recurrent tumors.Plerixafor was well tolerated with no drug-attributable grade 3 toxicities observed. He was the nephew and successor of Michael IV and the adoptive son of his wife Empress Zoe.He was popularly called "the Caulker" (Καλαφάτης, Kalaphates) in accordance with his father's original occupation. Conclusion No overall significant differences were found in susceptibility and R2* values of deep gray structures to suggest retained iron in the brain between ferumoxytol-exposed and unexposed children and young adults with arteriovenous malformations and in those exposed to ferumoxytol over time. The authors evaluated whether MRI enhanced with a blood pool ferumoxytol (Fe) contrast agent (Fe-MRI) can be used for surveillance of residual or recurrent AVMs.A retrospective cohort was assembled of children with an established AVM diagnosis who underwent surveillance by both DSA and 3-T Fe-MRI from 2014 to 2016. We also highlight current treatment strategies for specific lesions. The mean diameter of an intersected vessel was 1.0125 0.2227 mm. All of the radiologists surveyed to evaluate this automated method reported ease of software use and greater efficiency in report production. He currently serves as the Director of Brain Tumor Imaging at the Stanford Brain Tumor Center.

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